R4LOGIC / RESEARCH

Molecular research, biodiversity and scientific systems

R4Logic investigates biological questions using computational methods, public datasets and tools under development. Each research line presents its available evidence, evaluation criteria and methodological limitations.

PUBLISHED PREPRINT

A preprint with results and open analysis materials

The ChemRxiv preprint documents the CtMGAM results and links to an open analysis package. Its findings and methodological limitations inform the next stages of research.

PUBLISHED PREPRINT · CHEMRXIV

Chilean Papaya Bioprospecting for Human α-Glucosidase: Near-Native Pose Recovery in CtMGAM Docking

Roberto Pizarro Díaz · 2026 · ChemRxiv

In the human CtMGAM benchmark, near-native acarbose poses were recovered within the first three modes at both crystallographic copies. First-rank selection differed between copies: pose recovery and reliable selection are distinct achievements. A Chilean-papaya-inspired compound panel and an open analysis package connect this finding to computational bioprospecting. The panel remains unranked; biological activity requires biochemical testing.

ChemRxiv preprint · not peer reviewed · computational study

Figure 2 of the preprint: near-native acarbose poses were recovered at both CtMGAM copies, while consistent first-rank selection occurred only at B/D
Figure 2 · A pose can be recovered without being selected first. The two crystallographic copies show different selection outcomes. ChemRxiv · 2026 ↗
Read preprint Reproducibility package

RESEARCH CONTINUUM

From CtMGAM to COX-2 and Chilean biodiversity

A ChemRxiv preprint documents the CtMGAM findings. The research programme continues with COX-2 and biodiversity analysis using public data.

01PUBLISHED PREPRINT

CtMGAM

Chilean papaya bioprospecting

The study evaluates molecular docking against human CtMGAM using acarbose as a reference. Near-native poses appeared among the top three results in both crystallographic copies, but consistent first-rank selection occurred in only one. The compound panel inspired by Vasconcellea pubescens remains unranked.

Human CtMGAM · natural products · molecular docking

02IN DEVELOPMENT

COX-2

Extending the molecular investigation

The COX-2 research line examines how public data and computational methods can support comparisons under explicit evaluation criteria. The analysis is ongoing; no consolidated results are presented yet.

COX-2 · molecular modelling · workflow transfer

03IN DEVELOPMENT

Chilean Biodiversity

Underrepresented biodiversity in Chile

Mycetozoa Chile studies the diversity, distribution and evolutionary relationships of slime moulds using public occurrence records and sequence data. These organisms belong to Amoebozoa. The work seeks to identify gaps in the available biodiversity records.

Mycetozoa · public sequences · biodiversity informatics

RESEARCH INFRASTRUCTURE

R4Forge / Anvil

Explore infrastructure →

Anvil is a scientific-agent prototype under development within R4Forge. Its planned workflow combines input validation, tool execution and result evaluation with reproducible outputs. Molecular research provides an initial use case for testing this infrastructure.

ACADEMIC BACKGROUND

Current research and academic background

Earlier publications and academic experience are presented separately from the current research programme to clarify their distinct roles.

Review academic background →